Emergency services are at the scene of a serious collision on the A65 near Clapham.
The collision was reported at 2.50pm today and involves a HGV and a car.
The road is currently closed and will remain shut for several hours.
Diversions are in place. However, motorists have been advised to avoid the area, in particular HGVs.
North Yorkshire Police said they would issue an update when they had further information.